There are many different components inside the cannabis plant: over 100 different identified cannabinoids, along with terpenes and flavonoids. Each creates their own unique experiences, but together they can create enhanced or subdued effects in individuals. At least, that’s what the entourage theory says. 

Entourage Theory

The theory is that cannabinoids of various concentrations, along with terpenes and flavonoids, can create a better or unique experience. This is the entourage theory, also called the entourage effect. By combining different amounts together, there are varying effects for each individual.

Research shows a combination of cannabinoids can have a better effect than just straight THC, CBD or other cannabinoids on their own. By following these ideas, scientists have made some small conclusions that the entourage theory could have viability to it.

Within the human body are endocannabinoids, which are natural substances that react to different cannabinoids as they are consumed. Each cannabinoid creates a different sensation in the body depending on which receptor they connect to or avoid. These are the CB1 and CB2 receptors. The endocannabinoid system will connect different cannabinoids to one another, whether they come from the body or not. 

One reason that marijuana, specifically medicinal types, are so beneficial and effective as medicine is because of the entourage theory.

Research

Unfortunately it is hard to scientifically prove that the entourage theory is in fact effective. Much of the research available is based on patient and consumer testimonials along with anecdotal evidence. This poses a problem as these aren’t always definitive or reliable sources with concrete evidence. 

The theory first came about in 1998 when scientists looked at how different cannabinoids bonded with the CB1 and CB2 receptors. While some cannabinoids didn’t bond to the receptors, they did enhance the effects of the cannabinoid properties within the body of mice. So it’s not hard to think this theory would work the same in humans. Current research at the International Cannabis and Cannabinoids Institute in Prague is looking to do just that. However, the entourage theory may end up being almost impossible to prove with hard evidence. 

Future

While a lot of positives come from adding cannabinoids, like THC and CBD, together to create various effects, it may only be proved through anecdotal evidence. This doesn’t mean that the effects that people feel when they take combined cannabinoid products isn’t real. It just means they will be the only ones who know the feeling and can bring the validity to the theory. 

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